Structural Studies on Bioactive Compounds. Part 38. 1 Reactions of 5-Aminoimidazole-4-Carboxamide: Synthesis of Imidazo[1,5- a ]Quinazoline-3-Carboxamides †
Structural Studies on Bioactive Compounds. Part 38. 1 Reactions of 5-Aminoimidazole-4-Carboxamide: Synthesis of Imidazo[1,5- a ]Quinazoline-3-Carboxamides †
5-Aminoimidazole-4-carboxamide reacts with aromatic aldehydes to afford Schiff bases which can be cyclised to imidazo[1,5-a]quinazoline-3-carboxamides in DMF/sodium hydride. The potassium salt of imidazo[1,5-a]quinazoline-3-carboxylic acid undergoes deuterium exchange in D2O at the 1-position.
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