Chemical Reactivity of 3-aryl-5-Methyl-1,3,4-Oxadiazolin-2-Ones towards Nitrogen Nucleophiles. Part 1. One-pot Ring Conversion of 3-Aryl-5-Methyl-1,3,4-Oxadiazolin-2-Ones into 4-Amino-2-Aryl-5-Methyl-2,4-Dihydro-3 H -1,2,4-Triazol-3-Ones †
The ring transformation of 3-aryl-5-methyl-1,3,4-oxadiazolin-2-ones 1a–n into 4-amino-2-aryl-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-ones 3a–n, by reaction with hydrazine hydrate, is described. The products were screened for biological activity, and were found to be active against fungal strains.
BadamiB.V., and PuranikG. S., Indian J. Chem., 1974, 12, 671.
2.
BadamiB.V., and PuranikG. S., Rev. Roumaine Chim., 1982, 27, 281.
3.
MallurS.G., and BadamiB. V., IL Farmaco, 2000, 55, 65.
4.
(a) OhtaM., and KatoH., in Nonbenzenoid Aromatics, ed. SnyderJ. P., Academic Press, NewYork, 1969, p. 117; (b) J. C. Earl and A. W. Mackney, J. Chem. Soc., 1935, 899.
5.
(a) KametaniT., SotaK., and ShioM., J. Het. Chem., 1970, 7, 821; (b) H. Rupe and H. Gebhardt, Ber., 1899, 32, 10.
