Chemical Reactivity of 3-aryl-5-Methyl-1,3,4-Oxadiazolin-2-Ones towards Nitrogen Nucleophiles. Part 1. One-pot Ring Conversion of 3-Aryl-5-Methyl-1,3,4-Oxadiazolin-2-Ones into 4-Amino-2-Aryl-5-Methyl-2,4-Dihydro-3 H -1,2,4-Triazol-3-Ones †
Chemical Reactivity of 3-aryl-5-Methyl-1,3,4-Oxadiazolin-2-Ones towards Nitrogen Nucleophiles. Part 1. One-pot Ring Conversion of 3-Aryl-5-Methyl-1,3,4-Oxadiazolin-2-Ones into 4-Amino-2-Aryl-5-Methyl-2,4-Dihydro-3 H -1,2,4-Triazol-3-Ones †
The ring transformation of 3-aryl-5-methyl-1,3,4-oxadiazolin-2-ones 1a–n into 4-amino-2-aryl-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-ones 3a–n, by reaction with hydrazine hydrate, is described. The products were screened for biological activity, and were found to be active against fungal strains.
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