Novel Stereoselective Synthesis of (E)-α,β-Unsaturated Nitriles and Ketones by the Tandem reaction of Deprotonation–oxidation–Wittig Reaction from Phosphonium Salts †
Free accessOtherFirst published online January, 2003
Novel Stereoselective Synthesis of (E)-α,β-Unsaturated Nitriles and Ketones by the Tandem reaction of Deprotonation–oxidation–Wittig Reaction from Phosphonium Salts †
Phosphonium salt 1 and the alcohol 2 can undergo a tandem deprotonation–oxidation–Wittig reaction in the presence of sodium hydroxide and manganese dioxide, afford to an efficient method for the stereoselective synthesis of (E)-α,β-unsaturated nitriles and ketones 3.
