Regiospecific Nucleophilic Substitution of Fluorine in Fused Tetrafluoroquinolines with N - and O -Nucleophiles

Abstract

5,6,7,8-Tetrafluoro-1,2-azolo[3,4-b;4′,3′-e]quinolines react regiospecifically with aliphatic and aromatic amines, alcohols and phenols yielding 7-substituted 5,6,8-trifluoro-1,2-azolo[3,4-b;4′,3′-e]quinolines.