Regioselection in 1,3-Dipolar Cycloadditions of 3-Methylpyridine N -Imide to Aromatic Carbonitriles. Synthesis of 2-Aryl-8-Methyl[1,2,4]Triazolo [1,5- a ]Pyridines †
Free accessResearch articleFirst published online November, 2002
Regioselection in 1,3-Dipolar Cycloadditions of 3-Methylpyridine N -Imide to Aromatic Carbonitriles. Synthesis of 2-Aryl-8-Methyl[1,2,4]Triazolo [1,5- a ]Pyridines †
1-Amino-3-methylpyridinium mesitylenesulfonate (3) reacts with aromatic nitriles in the presence of potassium hydroxide, undergoing 1,3-dipolar cycloaddition followed by elimination of H2 to give 2-aryl-8-methyl[1,2,4]triazolo[1,5-a]pyridines as the major products, rather than the 6-methyl isomers.
