Abstract
A few water molecules attached to DNA have much longer residence times than expected, as established by NOE studies. It is now suggested that this arises because of the presence of long lived protein ‘caps’ spanning across the edges of the two DNA strands, thus trapping the water molecules underneath.
Keywords
References
1.
Wuthrich K.L.
,
Otting G.
, and
Liepinsk E.
, Faraday Discuss. , 1992 , 93 , 35 ; G. Otting and K. Wuthrich, J. Am. Chem. Soc. , 1989, 111 , 1871.
2.
Kubinec M.G.
, and
Wemmer D. E.
, J. Am. Chem. Soc. , 1992 , 114 , 8739 .
3.
Qian Y.
,
Otting G.
, and
Wuthrich K.
, J. Am Chem. Soc. , 1993 , 115 , 1189 .
4.
Affolter M.
,
Percival-Smith A.
,
Muller M.
,
Leupin W.
, and
Gehring W. J.
, Proc. Natl. Acad. Sci. USA , 1990 , 87 , 4093 .
5.
Symons M.C. R.
, Chem. Br. , 1989 , 25 , 491 ; M.C.R. Symons, Philos. Trans. R. Soc. , 1975, 272 , 13; M.C.R. Symons, Acc. Chem. Res. , 1981, 14 , 179.
6.
Symons M.C. R.
in Water and Aqueous Solutions ,
Neilson G.W.
, and
Enderby J. E.
(editors) Hilger , Bristol , 1986 , p. 41 .
7.
Symons M.C. R.
, J. Mol. Structure , 1993 , 297 , 133 .
8.
Strauss I.M.
, and
Symons M. C. R.
, J. Chem. Soc., Faraday Trans. I , 1978 , 74 , 2518 .