Amination of tert-butyl 4-bromobenzoate using PdCl2 (7% mol) and P(o-tolyl)3 provides a convenient route to N-substituted derivatives of tert-butyl 4-aminobenzoate.
References
1.
GuramA.S., RennelsR. A., and BuchwaldS. L., Angew. Chem. Int. Ed. Engl., 1995, 34, 1348.
2.
LouieJ., and HartwigJ. F., Tetrahedron Lett., 1995, 36, 3609.
3.
For recent reviews that cover the catalytic amination of aryl halides see: (a) FrostC.G., and MendoncaP. J., J. Chem. Soc., Perkin Trans. 1, 1998, 2615.
