Abstract
Reaction of amide 1, aldehyde 2, and amine 3 promoted by microwave irradiation produced monoacylaminals 4 up to 100% yield in a short time under solvent-free conditions.
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The times given in Table 1 are irradiation times. The intervals between irradiations must be considered and added.
40.4c was recrystallized from Benzene/petroleum ether and 4f, 4j and 4k were purified by chromatography on silica gel using Et2O/pentane as eluent.