Substituted 2-bromo-phenols can be synthesised by heating substituted cyclohexanones in neat diethyl dibromomalonate at 100°C. We discuss the efficiency of such a procedure and comment on the possible mechanism.
References
1.
NeriG., ViscoA. M., DonatoA., MiloneC., MalentacchiM., and GubitosaG., Applied Catalysis A-General, 1994, 100, 49.
2.
(a) WenzelT.T., JCS Chem. Commun., 1989, 932.
3.
A.S. Kotnis, Tetrahedron Lett., 1991, 32, 3441.
4.
(a) HorningsE.C., HorningsM. G., and WalkerG. N., J. Am. Chem. Soc., 1949, 169.
5.
TrostB.M., and MetznerP. J., J. Am. Chem. Soc., 1980, 102, 3572
6.
ItohY., BrossiA., HamelE., and LinC. M., Helv. Chim., Acta, 1988, 71, 199.
