Acid catalysed cyclisation occurs readily with HO(CH2)n+3P(O)(NHPh)Ph (n = 0 or 1) in MeOH but only acyclic HS(CH2)n+3P(O)(OMe)Ph is obtained when HS(CH2)n+3P(O)(NHPh)Ph (n = 0 or 1) is treated with HCl in CDCl3 containing 1% MeOH; cyclisation can occur if MeOH is excluded completely but even the five-membered cyclic thiophosphinate 5 (n= 0) is not formed readily.
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