Microbial Biotransformation of Cholic Acid to the New Potential Steroid Intermediate,9 α - Hydroxy – 3,12-Dioxo-23,24-Dinorchola-4,6-Dienoic Acid by Micrococcus Roseus †

Abstract

Fermentation of cholic acid with a strain of Micrococcus roseus isolated from soil by enrichment culture technique using cholic acid as the sole source of carbon yielded the metabolite, 9α-hydroxy-3, 12-dioxo-23, 24-dinorchola-4,6-dienoic acid as a single isolable product.