Oxidative cyclization of some 1-Aryl-5-(tetrazol-5-ylmethyl)pyrrolidin-2-ones and of a related piperidin-2-one. Preparation of fused tetracyclic tetrazolobenzodiazepinone derivatives

Abstract

In contrast to compounds of type 1a, compounds 1c–1i, when treated with lead(IV) acetate or cerium(IV) ammonium nitrate, underwent oxidative cyclizations to afford the corresponding compounds of type 3 with both oxidants, while oxidation of compound 1p afforded compound 2a (m = n = 1).