The synthesis of N-tosyl 2-aza [2,2,1] bicycloheptane substituted in 3-position by the α-chain of prostaglandins is described. This synthesis allowed the observation of two valuable transformations of the bicyclic framework: a ring expansion to a 2-aza [3,2,1] bicyclooctane derivative and a fragmentation to cis-1,3 disubstituted cyclopentyl amines.
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