The Knoevenagel condensation of carbonyl compounds with active methylene compounds proceeds smoothly in presence of potassium phosphate in commercial absolute ethanol to afford the desired products of good purity in moderate to excellent yields.
References
1.
JonesG.Organic Reactions, Wiley, New York, 1967, vol. 15, p. 204.
2.
LehnertW., Tetrahedron Lett., 1970, 54, 4723.
3.
Texier-BoulletF., and FoucaundA., Tetrahedron Lett., 1982, 23, 4927.
4.
CabelloJ.A., CampeloJ. M., GarciaA., LunaD., and MarinasJ. M., J. Org. Chem., 1984, 49, 5195.
5.
Shanthan RaoP., and VenkataratnamR. V., Tetrahedron Lett., 1991, 32, 5821.
6.
PrajapatiD., and SandhuJ. S., J. Chem. Soc., Perkin Trans.1., 1993, 739.
7.
VilleminD., and MartinB., J. Chem. Res(S)., 1994, 146.
8.
de la CruzP., Diez-BarraE., LoupyA., and LangaF., Tetrahedron Lett., 1996, 37, 1113.
9.
GowravaramG., ReddyB. V. S., BabuR. S., and YadavJ. S., Chem. Lett., 1998, 773.
10.
MitraA.K., and DeA., KarchaudhuriN., Synth. Commun., 1999, 29, 2731.