Despite the fact cancer is primarily a preventable disease, recent statistics indicate cancer will become the number one killer worldwide in 2010. Since certain cancers are more prevalent in the people of some countries than others, suggests the role of lifestyle. For instance cancer incidence among people from the Indian subcontinent, where most spices are consumed, is much lower than that in the Western World. Spices have been consumed for centuries for a variety of purposes—as flavoring agents, colorants, and preservatives. However, there is increasing evidence for the importance of plant-based foods in regular diet to lowering the risk of most chronic diseases, so spices are now emerging as more than just flavor aids, but as agents that can not only prevent but may even treat disease. In this article, we discuss the role of 41 common dietary spices with over 182 spice-derived nutraceuticals for their effects against different stages of tumorigenesis. Besides suppressing inflammatory pathways, spice-derived nutraceuticals can suppress survival, proliferation, invasion, and angiogenesis of tumor cells. We discuss how spice-derived nutraceuticals mediate such diverse effects and what their molecular targets are. Overall our review suggests “adding spice to your life” may serve as a healthy and delicious way to ward off cancer and other chronic diseases.
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References
1.
Kaefer CM, Milner JA. The role of herbs and spices in cancer prevention. J Nutr Biochem19:347–361, 2008.
2.
Anand P, Kunnumakkara AB, Sundaram C, Harikumar KB, Tharakan ST, Lai OS, Sung B, Aggarwal BB. Cancer is a preventable disease that requires major lifestyle changes. Pharm Res25:2097–2116, 2008.
3.
Brower V. Nutraceuticals: poised for a healthy slice of the healthcare market? Nat Biotechnol16:728–731, 1998.
4.
Zeisel SH. Regulation of “nutraceuticals”. Science (New York, NY)285:1853–1855, 1999.
5.
Miyajima Y, Kikuzaki H, Hisamoto M, Nikatani N. Antioxidative polyphenols from berries of Pimenta dioica. BioFactors (Oxford, England)21:301–303, 2004.
6.
Rodrigues VM, Rosa PT, Marques MO, Petenate AJ, Meireles MA. Supercritical extraction of essential oil from aniseed (Pimpinella anisum L) using CO2: solubility, kinetics, and composition data. J Agric Food Chem51:1518–1523, 2003.
7.
Eigner D, Scholz D. Ferula asafoetida and Curcuma longa in traditional medical treatment and diet in Nepal. J Ethnopharmacol67: 1–6, 1999.
8.
Grayer RJ, Kite GC, Goldstone FJ, Bryan SE, Paton A, Putievsky E. Infraspecific taxonomy and essential oil chemotypes in sweet basil, Ocimum basilicum. Phytochemistry43:1033–1039, 1996.
9.
Conforti F, Statti G, Uzunov D, Menichini F. Comparative chemical composition and antioxidant activities of wild and cultivated Laurus nobilis L. leaves and Foeniculum vulgare subsp. piperitum (Ucria) coutinho seeds. Biol Pharm Bull29:2056–2064, 2006.
10.
Musenga A, Mandrioli R, Ferranti A, D’Orazio G, Fanali S, Raggi MA. Analysis of aromatic and terpenic constituents of pepper extracts by capillary electrochromatography. J Sep Sci30:612–619, 2007.
11.
Iacobellis NS, Lo Cantore P, Capasso F, Senatore F. Antibacterial activity of Cuminum cyminum L. and Carum carvi L. essential oils. J Agric Food Chem53:57–61, 2005.
12.
Richter J, Schellenberg I. Comparison of different extraction methods for the determination of essential oils and related compounds from aromatic plants and optimization of solid-phase microextraction/gas chromatography. Anal Bioanal Chem387:2207–2217, 2007.
13.
Marongiu B, Piras A, Porcedda S. Comparative analysis of the oil and supercritical CO2 extract of Elettaria cardamomum (L.) Maton. J Agric Food Chem52:6278–6282, 2004.
14.
Saleh MM, Zwaving JH, Malingre TM, Bos R. The essential oil of Apium graveolens var. secalinum and its cercaricidal activity. Pharm Weekbl Sci7:277–279, 1985.
15.
Fejes S, Blazovics A, Lugasi A, Lemberkovics E, Petri G, Kery A. In vitro antioxidant activity of Anthriscus cerefolium L. (Hoffm.) extracts. J Ethnopharmacol69:259–265, 2000.
16.
Tazaburo K, Masao K. Studies on the constituents of Anthriscus sylvestris Hoffm. on the components of the flower and leaves. Yakugaku Zasshi99:602–606, 1979.
17.
Hashimoto S, Miyazawa M, Kameoka H. Volatile flavor components of chive (Allium schoenoprasum L.). J Food Sci48:1858–1859, 1983.
18.
Jayaprakasha GK, Jagan Mohan Rao L, Sakariah KK. Volatile constituents from Cinnamomum zeylanicum fruit stalks and their antioxidant activities. J Agric Food Chem51:4344–4348, 2003.
19.
Chaieb K, Hajlaoui H, Zmantar T, Kahla-Nakbi AB, Rouabhia M, Mahdouani K, Bakhrouf A. The chemical composition and biological activity of clove essential oil, Eugenia caryophyllata (Syzigium aromaticum L. Myrtaceae): a short review. Phytother Res21:501–506, 2007.
20.
Smallfield BM, van Klink JW, Perry NB, Dodds KG. Coriander spice oil: effects of fruit crushing and distillation time on yield and composition. J Agric Food Chem49:118–123, 2001.
Khalaf AF. Toxicological efficacy of some indigenous dill compounds against the flesh fly, Parasarcophaga dux Thomson. J Egypt Soc Parasitol34:227–237, 2004.
23.
Barazani O, Fait A, Cohen Y, Diminshtein S, Ravid U, Putievsky E, Lewinsohn E, Friedman J. Chemical variation among indigenous populations of Foeniculum vulgare var. vulgare in Israel. Planta Med65:486–489, 1999.
24.
Zeller A, Rychlik M. Character impact odorants of fennel fruits and fennel tea. J Agric Food Chem54:3686–3692, 2006.
25.
Kimbaris AC, Siatis NG, Daferera DJ, Tarantilis PA, Pappas CS, Polissiou MG. Comparison of distillation and ultrasound-assisted extraction methods for the isolation of sensitive aroma compounds from garlic (Allium sativum). Ultrason Sonochem13:54–60, 2006.
Park IK, Choi KS, Kim DH, Choi IH, Kim LS, Bak WC, Choi JW, Shin SC. Fumigant activity of plant essential oils and components from horseradish (Armoracia rusticana), anise (Pimpinella anisum) and garlic (Allium sativum) oils against Lycoriella ingenua (Diptera: Sciaridae). Pest Manag Sci62:723–728, 2006.
29.
Diaz-Maroto MC, Perez-Coello MS, Gonzalez Vinas MA, Cabezudo MD. Influence of drying on the flavor quality of spearmint (Mentha spicata L.). J Agric Food Chem51:1265–1269, 2003.
30.
Munday R, Munday CM. Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: comparison of allyl isothiocyanate with sulforaphane and related compounds. J Agric Food Chem52:1867–1871, 2004.
31.
Qiu Q, Zhang G, Sun X, Liu X. [Study on chemical constituents of the essential oil from Myristica fragrans Houtt. by supercritical fluid extraction and steam distillation]. Zhong Yao Cai27:823–826, 2004.
32.
Yuan ZM, Wang J, Lv J, Jia TZ. [Comparing analysis of components in volatile oils of nutmeg and prepared nutmeg by GC-MS]. Zhongguo Zhong Yao Za Zhi31:737–739, 2006.
33.
Ly TN, Hazama C, Shimoyamada M, Ando H, Kato K, Yamauchi R. Antioxidative compounds from the outer scales of onion. J Agric Food Chem53:8183–8189, 2005.
34.
Wang HX, Ng TB. Isolation of allicepin, a novel antifungal peptide from onion (Allium cepa) bulbs. J Pept Sci10:173–177, 2004.
35.
Rodrigues MR, Krause LC, Caramao EB, dos Santos JG, Dariva C, Vladimir de Oliveira J. Chemical composition and extraction yield of the extract of Origanum vulgare obtained from sub- and supercritical CO2. J Agric Food Chem52:3042–3047, 2004.
36.
Gnayfeed MH, Daood HG, Illes V, Biacs PA. Supercritical CO(2) and subcritical propane extraction of pungent paprika and quantification of carotenoids, tocopherols, and capsaicinoids. J Agric Food Chem49: 2761–2766, 2001.
37.
Lopez MG, Sanchez-Mendoza IR, Ochoa-Alejo N. Comparative study of volatile components and fatty acids of plants and in vitro cultures of parsley (Petroselinum crispum (Mill) nym ex hill). J Agric Food Chem47:3292–3296, 1999.
38.
Krist S, Stuebiger G, Unterweger H, Bandion F, Buchbauer G. Analysis of volatile compounds and triglycerides of seed oils extracted from different poppy varieties (Papaver somniferum L.). J Agric Food Chem53:8310–8316, 2005.
39.
Howard LR, Talcott ST, Brenes CH, Villalon B. Changes in phytochemical and antioxidant activity of selected pepper cultivars (Capsicum species) as influenced by maturity. J Agric Food Chem48: 1713–1720, 2000.
40.
Bozin B, Mimica-Dukic N, Samojlik I, Jovin E. Antimicrobial and antioxidant properties of rosemary and sage (Rosmarinus officinalis L. and Salvia officinalis L., Lamiaceae) essential oils. J Agric Food Chem55:7879–7885, 2007.
41.
Carmona M, Zalacain A, Pardo JE, Lopez E, Alvarruiz A, Alonso GL. Influence of different drying and aging conditions on saffron constituents. J Agric Food Chem53:3974–3979, 2005.
42.
Raal A, Orav A, Arak E. Composition of the essential oil of Salvia officinalis L. from various European countries. Nat Prod Res21:406–411, 2007.
43.
Lampronti I, Saab AM, Gambari R. Antiproliferative activity of essential oils derived from plants belonging to the Magnoliophyta division. Int J Oncol29:989–995, 2006.
44.
Crews C, Hough P, Brereton P, Godward J, Lees M, Guiet S, Winkelmann W. Quantitation of the main constituents of some authentic sesame seed oils of different origin. J Agric Food Chem54: 6266–6270, 2006.
45.
Pino JA, Marbot R, Vazquez C. Volatile components of tamarind (Tamarindus indica L.) grown in Cuba. J Essent Oil Res16:318–320, 2004.
46.
Kordali S, Kotan R, Mavi A, Cakir A, Ala A, Yildirim A. Determination of the chemical composition and antioxidant activity of the essential oil of Artemisia dracunculus and of the antifungal and antibacterial activities of Turkish Artemisia absinthium, A. dracunculus, Artemisia santonicum, and Artemisia spicigera essential oils. J Agric Food Chem53:9452–9458, 2005.
47.
Hudaib M, Speroni E, Di Pietra AM, Cavrini V. GC/MS evaluation of thyme (Thymus vulgaris L.) oil composition and variations during the vegetative cycle. J Pharm Biomed Anal29:691–700, 2002.
48.
Braga ME, Leal PF, Carvalho JE, Meireles MA. Comparison of yield, composition, and antioxidant activity of turmeric (Curcuma longa L.) extracts obtained using various techniques. J Agric Food Chem51: 6604–6611, 2003.
49.
Sinha AK, Verma SC, Sharma UK. Development and validation of an RP-HPLC method for quantitative determination of vanillin and related phenolic compounds in Vanilla planifolia. J Sep Sci30:15–20, 2007.
50.
Jirovetz L, Buchbauer G, Ngassoum MB, Geissler M. Aroma compound analysis of Piper nigrum and Piper guineense essential oils from Cameroon using solid-phase microextraction-gas chromatography, solid-phase microextraction-gas chromatography-mass spectrometry and olfactometry. J Chromatogr976:265–275, 2002.
51.
Chainy GB, Manna SK, Chaturvedi MM, Aggarwal BB. Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-kappaB, AP-1, JNK, MAPKK and apoptosis. Oncogene19:2943–2950, 2000.
52.
Lo AH, Liang YC, Lin-Shiau SY, Ho CT, Lin JK. Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kappaB in mouse macrophages. Carcinogenesis23:983–991, 2002.
53.
Medeiros R, Passos GF, Vitor CE, Koepp J, Mazzuco TL, Pianowski LF, Campos MM, Calixto JB. Effect of two active compounds obtained from the essential oil of Cordia verbenacea on the acute inflammatory responses elicited by LPS in the rat paw. Br J Pharmacol151:618–627, 2007.
54.
Kim DH, Kim CH, Kim MS, Kim JY, Jung KJ, Chung JH, An WG, Lee JW, Yu BP, Chung HY. Suppression of age-related inflammatory NF-kappaB activation by cinnamaldehyde. Biogerontology8:545–554, 2007.
55.
Marin YE, Wall BA, Wang S, Namkoong J, Martino JJ, Suh J, Lee HJ, Rabson AB, Yang CS, Chen S, Ryu JH. Curcumin downregulates the constitutive activity of NF-kappaB and induces apoptosis in novel mouse melanoma cells. Melanoma Res17:274–283, 2007.
56.
Berchtold CM, Chen KS, Miyamoto S, Gould MN. Perillyl alcohol inhibits a calcium-dependent constitutive nuclear factor-kappaB pathway. Cancer Res65:8558–8566, 2005.
57.
Min YD, Choi CH, Bark H, Son HY, Park HH, Lee S, Park JW, Park EK, Shin HI, Kim SH. Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-kappaB and p38 MAPK in HMC-1 human mast cell line. Inflamm Res56:210–215, 2007.
58.
Xu C, Shen G, Chen C, Gelinas C, Kong AN. Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells. Oncogene24:4486–4495, 2005.
59.
Shishodia S, Majumdar S, Banerjee S, Aggarwal BB. Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1. Cancer Res63:4375–4383, 2003.
60.
Taylor P, Noriega R, Farah C, Abad MJ, Arsenak M, Apitz R. Ajoene inhibits both primary tumor growth and metastasis of B16/BL6 melanoma cells in C57BL/6 mice. Cancer Lett239:298–304, 2006.
61.
Lang A, Lahav M, Sakhnini E, Barshack I, Fidder HH, Avidan B, Bardan E, Hershkoviz R, Bar-Meir S, Chowers Y. Allicin inhibits spontaneous and TNF-alpha induced secretion of proinflammatory cytokines and chemokines from intestinal epithelial cells. Clin Nutr23:1199–1208, 2004.
62.
Woo HM, Kang JH, Kawada T, Yoo H, Sung MK, Yu R. Active spice-derived components can inhibit inflammatory responses of adipose tissue in obesity by suppressing inflammatory actions of macrophages and release of monocyte chemoattractant protein-1 from adipocytes. Life Sci80:926–931, 2007.
63.
Kowalski J, Samojedny A, Paul M, Pietsz G, Wilczok T. Effect of apigenin, kaempferol and resveratrol on the expression of interleukin-1beta and tumor necrosis factor-alpha genes in J774.2 macrophages. Pharmacol Rep57:390–394, 2005.
64.
Thejass P, Kuttan G. Antiangiogenic activity of Diallyl Sulfide (DAS). Int Immunopharmacol7:295–305, 2007.
65.
Lee YY, Hung SL, Pai SF, Lee YH, Yang SF. Eugenol suppressed the expression of lipopolysaccharide-induced proinflammatory mediators in human macrophages. J Endod33:698–702, 2007.
66.
Tripathi S, Maier KG, Bruch D, Kittur DS. Effect of 6-gingerol on pro-inflammatory cytokine production and costimulatory molecule expression in murine peritoneal macrophages. J Surg Res138:209–213, 2007.
67.
Surh YJ, Park KK, Chun KS, Lee LJ, Lee E, Lee SS. Anti-tumor-promoting activities of selected pungent phenolic substances present in ginger. J Environ Pathol Toxicol Oncol18:131–139, 1999.
68.
Pradeep CR, Kuttan G. Piperine is a potent inhibitor of nuclear factor-kappaB (NF-kappaB), c-Fos, CREB, ATF-2 and proinflammatory cytokine gene expression in B16F-10 melanoma cells. Int Immunopharmacol4:1795–1803, 2004.
69.
Weglarz L, Wawszczyk J, Orchel A, Jaworska-Kik M, Dzierzewicz Z. Phytic acid modulates in vitro IL-8 and IL-6 release from colonic epithelial cells stimulated with LPS and IL-1beta. Dig Dis Sci52:93–102, 2007.
70.
Bhutani M, Pathak AK, Nair AS, Kunnumakkara AB, Guha S, Sethi G, Aggarwal BB. Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation. Clin Cancer Res13:3024–3032, 2007.
71.
Li M, Min JM, Cui JR, Zhang LH, Wang K, Valette A, Davrinche C, Wright M, Leung-Tack J. Z-ajoene induces apoptosis of HL-60 cells: involvement of Bcl-2 cleavage. Nutr Cancer42:241–247, 2002.
72.
Xiao D, Srivastava SK, Lew KL, Zeng Y, Hershberger P, Johnson CS, Trump DL, Singh SV. Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis. Carcinogenesis24:891–897, 2003.
73.
Palozza P, Serini S, Maggiano N, Angelini M, Boninsegna A, Di Nicuolo F, Ranelletti FO, Calviello G. Induction of cell cycle arrest and apoptosis in human colon adenocarcinoma cell lines by beta-carotene through down-regulation of cyclin A and Bcl-2 family proteins. Carcinogenesis23:11–18, 2002.
74.
Park C, Moon DO, Rhu CH, Choi BT, Lee WH, Kim GY, Choi YH. Beta-sitosterol induces anti-proliferation and apoptosis in human leukemic U937 cells through activation of caspase-3 and induction of Bax/Bcl-2 ratio. Biol Pharm Bull30:1317–1323, 2007.
75.
Dorrie J, Sapala K, Zunino SJ. Carnosol-induced apoptosis and downregulation of Bcl-2 in B-lineage leukemia cells. Cancer Lett170: 33–39, 2001.
76.
Wu SJ, Ng LT, Lin CC. Cinnamaldehyde-induced apoptosis in human PLC/PRF/5 cells through activation of the proapoptotic Bcl-2 family proteins and MAPK pathway. Life Sci77:938–951, 2005.
77.
Liu B, Bai QX, Chen XQ, Gao GX, Gu HT. [Effect of curcumin on expression of survivin, Bcl-2 and Bax in human multiple myeloma cell line]. Zhongguo Shi Yan Xue Ye Xue Za Zhi15:762–766, 2007.
78.
Kalra N, Arora A, Shukla Y. Involvement of multiple signaling pathways in diallyl sulfide mediated apoptosis in mouse skin tumors. Asian Pac J Cancer Prev7:556–562, 2006.
79.
Wang CC, Chen LG, Lee LT, Yang LL. Effects of 6-gingerol, an antioxidant from ginger, on inducing apoptosis in human leukemic HL-60 cells. In Vivo17:641–645, 2003.
80.
Guo XM, Lu Q, Liu ZJ, Wang LF, Feng BA. [Effects of D-limonene on leukemia cells HL-60 and K562 in vitro]. Zhongguo Shi Yan Xue Ye Xue Za Zhi14:692–695, 2006.
81.
Pei YX, Heng ZC, Duan GC, Zhang ZZ, Wang MC, Hu CL, Gao DL. [Effects and mechanism of lutein on apoptosis of esophageal carcinoma EC9706 cells]. Zhongguo Zhong Yao Za Zhi32:332–334, 354, 2007.
82.
Kolettas E, Thomas C, Leneti E, Skoufos I, Mbatsi C, Sisoula C, Manos G, Evangelou A. Rosmarinic acid failed to suppress hydrogen peroxide-mediated apoptosis but induced apoptosis of Jurkat cells which was suppressed by Bcl-2. Mol Cell Biochem285:111–120, 2006.
83.
Balasenthil S, Rao KS, Nagini S. Apoptosis induction by S-allylcysteine, a garlic constituent, during 7,12-dimethylbenz[a]anthra-cene-induced hamster buccal pouch carcinogenesis. Cell Biochem Funct20:263–268, 2002.
84.
Pledgie-Tracy A, Sobolewski MD, Davidson NE. Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines. Mol Cancer Ther6:1013–1021, 2007.
85.
Tan J, Shen ZX, Geng W. [Ursolic acid induces apoptosis in colon cancer HT-29 cells]. Zhonghua Zhong Liu Za Zhi28:99–102, 2006.
86.
Oommen S, Anto RJ, Srinivas G, Karunagaran D. Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells. Eur J Pharmacol485:97–103, 2004.
87.
Dudai N, Weinstein Y, Krup M, Rabinski T, Ofir R. Citral is a new inducer of caspase-3 in tumor cell lines. Planta Med71:484–488, 2005.
88.
Lu HF, Sue CC, Yu CS, Chen SC, Chen GW, Chung JG. Diallyl disulfide (DADS) induced apoptosis undergo caspase-3 activity in human bladder cancer T24 cells. Food Chem Toxicol42:1543–1552, 2004.
89.
Hosono T, Fukao T, Ogihara J, Ito Y, Shiba H, Seki T, Ariga T. Diallyl trisulfide suppresses the proliferation and induces apoptosis of human colon cancer cells through oxidative modification of beta-tubulin. J Biol Chem280:41487–41493, 2005.
90.
Leung HW, Lin CJ, Hour MJ, Yang WH, Wang MY, Lee HZ. Kaempferol induces apoptosis in human lung non-small carcinoma cells accompanied by an induction of antioxidant enzymes. Food Chem Toxicol45:2005–2013, 2007.
91.
Ji J, Zhang L, Wu YY, Zhu XY, Lv SQ, Sun XZ. Induction of apoptosis by d-limonene is mediated by a caspase-dependent mitochondrial death pathway in human leukemia cells. Leuk Lymphoma47:2617–2624, 2006.
92.
Lee BK, Kim JH, Jung JW, Choi JW, Han ES, Lee SH, Ko KH, Ryu JH. Myristicin-induced neurotoxicity in human neuroblastoma SK-N-SH cells. Toxicol Lett157:49–56, 2005.
93.
Keum YS, Kim J, Lee KH, Park KK, Surh YJ, Lee JM, Lee SS, Yoon JH, Joo SY, Cha IH, Yook JI. Induction of apoptosis and caspase-3 activation by chemopreventive [6]-paradol and structurally related compounds in KB cells. Cancer Lett177:41–47, 2002.
94.
Calcabrini A, Stringaro A, Toccacieli L, Meschini S, Marra M, Colone M, Salvatore G, Mondello F, Arancia G, Molinari A. Terpinen-4-ol, the main component of Melaleuca alternifolia (tea tree) oil inhibits the in vitro growth of human melanoma cells. J Invest Dermatol122:349–360, 2004.
95.
Chen CY, Liu TZ, Liu YW, Tseng WC, Liu RH, Lu FJ, Lin YS, Kuo SH, Chen CH. 6-shogaol (alkanone from ginger) induces apoptotic cell death of human hepatoma p53 mutant Mahlavu subline via an oxidative stress-mediated caspase-dependent mechanism. J Agric Food Chem55:948–954, 2007.
96.
Chew BP, Brown CM, Park JS, Mixter PF. Dietary lutein inhibits mouse mammary tumor growth by regulating angiogenesis and apoptosis. Anticancer Res23:3333–3339, 2003.
97.
Shukla S, MacLennan GT, Flask CA, Fu P, Mishra A, Resnick MI, Gupta S. Blockade of beta-catenin signaling by plant flavonoid apigenin suppresses prostate carcinogenesis in TRAMP mice. Cancer Res67:6925–6935, 2007.
98.
Clark SS. Perillyl alcohol induces c-Myc-dependent apoptosis in Bcr/Abl-transformed leukemia cells. Oncology70:13–18, 2006.
99.
LoTempio MM, Veena MS, Steele HL, Ramamurthy B, Ramalingam TS, Cohen AN, Chakrabarti R, Srivatsan ES, Wang MB. Curcumin suppresses growth of head and neck squamous cell carcinoma. Clin Cancer Res11:6994–7002, 2005.
100.
Pei YX, Heng ZC, Duan GC, Wang MC. [The mechanisms and effects of lutein on inducing the cell differentiation of human esophagus cancer EC9706]. Sichuan Da Xue Xue Bao Yi Xue Ban38: 629–632, 2007.
101.
Yokota T, Matsuzaki Y, Koyama M, Hitomi T, Kawanaka M, Enoki-Konishi M, Okuyama Y, Takayasu J, Nishino H, Nishikawa A, Osawa T, Sakai T. Sesamin, a lignan of sesame, down-regulates cyclin D1 protein expression in human tumor cells. Cancer Sci98:1447–1453, 2007.
102.
Chaudhuri D, Orsulic S, Ashok BT. Antiproliferative activity of sulforaphane in Akt-overexpressing ovarian cancer cells. Mol Cancer Ther6:334–345, 2007.
103.
Lee YM, Wu TH, Chen SF, Chung JG. Effect of 5-methoxypsoralen (5-MOP) on cell apoptosis and cell cycle in human hepatocellular carcinoma cell line. Toxicol In Vitro17:279–287, 2003.
104.
Visanji JM, Thompson DG, Padfield PJ. Induction of G2/M phase cell cycle arrest by carnosol and carnosic acid is associated with alteration of cyclin A and cyclin B1 levels. Cancer Lett237:130–136, 2006.
105.
Wiseman DA, Werner SR, Crowell PL. Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells. J Pharmacol Exp Ther320:1163–1170, 2007.
106.
Saied IT, Shamsuddin AM. Up-regulation of the tumor suppressor gene p53 and WAF1 gene expression by IP6 in HT-29 human colon carcinoma cell line. Anticancer Res18:1479–1484, 1998.
107.
Hung H. Dietary quercetin inhibits proliferation of lung carcinoma cells. Forum Nutr60:146–157, 2007.
108.
Hwang ES, Lee HJ. Allyl isothiocyanate and its N-acetylcysteine conjugate suppress metastasis via inhibition of invasion, migration, and matrix metalloproteinase-2/-9 activities in SK-Hep 1 human hepatoma cells. Exp Biol Med (Maywood)231:421–430, 2006.
109.
Park WH, Kim SH, Kim CH. A new matrix metalloproteinase-9 inhibitor 3,4-dihydroxycinnamic acid (caffeic acid) from methanol extract of Euonymus alatus: isolation and structure determination. Toxicology207:383–390, 2005.
110.
Huang SC, Ho CT, Lin-Shiau SY, Lin JK. Carnosol inhibits the invasion of B16/F10 mouse melanoma cells by suppressing metal-loproteinase-9 through down-regulating nuclear factor-kappa B and c-Jun. Biochem Pharmacol69:221–232, 2005.
111.
Vijayababu MR, Arunkumar A, Kanagaraj P, Venkataraman P, Krishnamoorthy G, Arunakaran J. Quercetin downregulates matrix metalloproteinases 2 and 9 proteins expression in prostate cancer cells (PC-3). Mol Cell Biochem287:109–116, 2006.
112.
Cha HJ, Park MT, Chung HY, Kim ND, Sato H, Seiki M, Kim KW. Ursolic acid-induced down-regulation of MMP-9 gene is mediated through the nuclear translocation of glucocorticoid receptor in HT1080 human fibrosarcoma cells. Oncogene16:771–778, 1998.
113.
Lirdprapamongkol K, Sakurai H, Kawasaki N, Choo MK, Saitoh Y, Aozuka Y, Singhirunnusorn P, Ruchirawat S, Svasti J, Saiki I. Vanillin suppresses in vitro invasion and in vivo metastasis of mouse breast cancer cells. Eur J Pharm Sci25:57–65, 2005.
114.
Su CC, Chen GW, Lin JG, Wu LT, Chung JG. Curcumin inhibits cell migration of human colon cancer colo 205 cells through the inhibition of nuclear factor kappa B/p65 and down-regulates cyclooxygenase-2 and matrix metalloproteinase-2 expressions. Anticancer Res26:1281–1288, 2006.
115.
Mitra A, Chakrabarti J, Banerji A, Chatterjee A, Das BR. Curcumin, a potential inhibitor of MMP-2 in human laryngeal squamous carcinoma cells HEp2. J Environ Pathol Toxicol Oncol25:679–690, 2006.
116.
Ko CH, Shen SC, Lee TJ, Chen YC. Myricetin inhibits matrix metalloproteinase 2 protein expression and enzyme activity in colorectal carcinoma cells. Mol Cancer Ther4:281–290, 2005.
117.
Xiang M, Qian ZY, Zhou CH, Liu J, Li WN. Crocetin inhibits leukocyte adherence to vascular endothelial cells induced by AGEs. J Ethnopharmacol107:25–31, 2006.
118.
Thejass P, Kuttan G. Antimetastatic activity of Sulforaphane. Life Sci78:3043–3050, 2006.
119.
Chen CC, Chow MP, Huang WC, Lin YC, Chang YJ. Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure-activity relationships. Mol Pharmacol66:683–693, 2004.
120.
Mo SJ, Son EW, Rhee DK, Pyo S. Modulation of TNF-alpha-induced ICAM-1 expression, NO and H2O2 production by alginate, allicin and ascorbic acid in human endothelial cells. Arch Pharm Res26:244–251, 2003.
121.
Mousa AS, Mousa SA. Anti-angiogenesis efficacy of the garlic ingredient alliin and antioxidants: role of nitric oxide and p53. Nutr Cancer53:104–110, 2005.
122.
Jung JE, Kim HS, Lee CS, Park DH, Kim YN, Lee MJ, Lee JW, Park JW, Kim MS, Ye SK, Chung MH. Caffeic acid and its synthetic derivative CADPE suppress tumor angiogenesis by blocking STAT3-mediated VEGF expression in human renal carcinoma cells. Carcinogenesis28:1780–1787, 2007.
123.
Min JK, Han KY, Kim EC, Kim YM, Lee SW, Kim OH, Kim KW, Gho YS, Kwon YG. Capsaicin inhibits in vitro and in vivo angiogenesis. Cancer Res64:644–651, 2004.
124.
Chen WH, Chen Y, Cui GH. Effects of TNF-alpha and curcumin on the expression of VEGF in Raji and U937 cells and on angiogenesis in ECV304 cells. Chin Med J (Engl)118:2052–2057, 2005.
125.
Fan ZL, Qi ZH, Xie Y. [Effect of diallyl disulfide on the expression and secretion of VEGF in HL-60 cells]. Zhonghua Xue Ye Xue Za Zhi27:626–629, 2006.
126.
Kim EC, Min JK, Kim TY, Lee SJ, Yang HO, Han S, Kim YM, Kwon YG. [6]-Gingerol, a pungent ingredient of ginger, inhibits angio-genesis in vitro and in vivo. Biochem Biophys Res Commun335: 300–308, 2005.
127.
Loutrari H, Hatziapostolou M, Skouridou V, Papadimitriou E, Roussos C, Kolisis FN, Papapetropoulos A. Perillyl alcohol is an angiogenesis inhibitor. J Pharmacol Exp Ther311:568–575, 2004.
128.
Huang SS, Zheng RL. Rosmarinic acid inhibits angiogenesis and its mechanism of action in vitro. Cancer Lett239:271–280, 2006.
129.
Rizvi I, Riggs DR, Jackson BJ, Ng A, Cunningham C, McFadden DW. Inositol hexaphosphate (IP6) inhibits cellular proliferation in melanoma. J Surg Res133:3–6, 2006.
130.
McMillan B, Riggs DR, Jackson BJ, Cunningham C, McFadden DW. Dietary influence on pancreatic cancer growth by catechin and inositol hexaphosphate. J Surg Res141:115–119, 2007.
131.
Coussens LM, Werb Z. Inflammation and cancer. Nature420:860–867, 2002.
132.
Lu H, Ouyang W, Huang C. Inflammation, a key event in cancer development. Mol Cancer Res4:221–233, 2006.
133.
Garg A, Aggarwal BB. Nuclear transcription factor-kappaB as a target for cancer drug development. Leukemia16:1053–1068, 2002.
134.
Bonizzi G, Karin M. The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol25:280–288, 2004.
135.
Kumar A, Takada Y, Boriek AM, Aggarwal BB. Nuclear factor-kappaB: its role in health and disease. J Mol Med82:434–448, 2004.
136.
Aggarwal BB, Vijayalekshmi RV, Sung B. Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe. Clin Cancer Res15:425–430, 2009.
137.
Xie K. Interleukin-8 and human cancer biology. Cytokine Growth Factor Rev12:375–391, 2001.
138.
Cortes JR, Perez GM, Rivas MD, Zamorano J. Kaempferol inhibits IL-4-induced STAT6 activation by specifically targeting JAK3. J Immunol179:3881–3887, 2007.
139.
Souza MC, Siani AC, Ramos MF, Menezes-de-Lima OJ, Henriques MG. Evaluation of anti-inflammatory activity of essential oils from two Asteraceae species. Pharmazie58:582–586, 2003.
140.
Woo ER, Pokharel YR, Yang JW, Lee SY, Kang KW. Inhibition of nuclear factor-kappaB activation by 2′,8″-biapigenin. Biol Pharm Bull29:976–980, 2006.
141.
Anandakumar P, Kamaraj S, Jagan S, Ramakrishnan G, Vinodhkumar R, Devaki T. Capsaicin modulates pulmonary antioxidant defense system during benzo(a)pyrene-induced lung cancer in Swiss albino mice. Phytother Res22:529–533, 2008.
142.
Jeyabal PV, Syed MB, Venkataraman M, Sambandham JK, Sakthisekaran D. Apigenin inhibits oxidative stress-induced macro-molecular damage in N-nitrosodiethylamine (NDEA)-induced hep-atocellular carcinogenesis in Wistar albino rats. Mol Carcinog44:11–20, 2005.
143.
Kim SS, Oh OJ, Min HY, Park EJ, Kim Y, Park HJ, Nam Han Y, Lee SK. Eugenol suppresses cyclooxygenase-2 expression in lipopoly-saccharide-stimulated mouse macrophage RAW264.7 cells. Life Sci73:337–348, 2003.
144.
Girdhani S, Bhosle SM, Thulsidas SA, Kumar A, Mishra KP. Potential of radiosensitizing agents in cancer chemo-radiotherapy. J Cancer Res Ther1:129–131, 2005.
145.
Young SC, Wang CJ, Hsu JD, Hsu JL, Chou FP. Increased sensitivity of Hep G2 cells toward the cytotoxicity of cisplatin by the treatment of piper betel leaf extract. Arch Toxicol80:319–327, 2006.
146.
Dange P, Sarma H, Pandey BN, Mishra KP. Radiation-induced incidence of thymic lymphoma in mice and its prevention by antioxidants. J Environ Pathol Toxicol Oncol26:273–279, 2007.
147.
Singh A, Singh SP, Bamezai R. Modulatory potential of clocimum oil on mouse skin papillomagenesis and the xenobiotic detoxication system. Food Chem Toxicol37:663–670, 1999.
148.
Krishnaswamy K, Raghuramulu N. Bioactive phytochemicals with emphasis on dietary practices. Indian J Med Res108:167–181, 1998.
149.
Rompelberg CJ, Steenwinkel MJ, van Asten JG, van Delft JH, Baan RA, Verhagen H. Effect of eugenol on the mutagenicity of benzo[a]pyrene and the formation of benzo[a]pyrene-DNA adducts in the lambda-lacZ-transgenic mouse. Mutat Res369:87–96, 1996.
150.
Sukumaran K, Kuttan R. Inhibition of tobacco-induced mutagenesis by eugenol and plant extracts. Mutat Res343:25–30, 1995.
151.
Jeng JH, Hahn LJ, Lu FJ, Wang YJ, Kuo MY. Eugenol triggers different pathobiological effects on human oral mucosal fibroblasts. J Dent Res73:1050–1055, 1994.
152.
Yokota H, Hashimoto H, Motoya M, Yuasa A. Enhancement of UDP-glucuronyltransferase, UDP-glucose dehydrogenase, and glutathione S-transferase activities in rat liver by dietary administration of eugenol. Biochem Pharmacol37:799–802, 1988.
153.
Ahmed N, Laverick L, Sammons J, Zhang H, Maslin DJ, Hassan HT. Ajoene, a garlic-derived natural compound, enhances chemotherapy-induced apoptosis in human myeloid leukaemia CD34-positive resistant cells. Anticancer Res21:3519–3523, 2001.
154.
Tang L, Zhang Y. Mitochondria are the primary target in isothiocyanate-induced apoptosis in human bladder cancer cells. Mol Cancer Ther4:1250–1259, 2005.
155.
Sanchez AM, Malagarie-Cazenave S, Olea N, Vara D, Chiloeches A, Diaz-Laviada I. Apoptosis induced by capsaicin in prostate PC-3 cells involves ceramide accumulation, neutral sphingomyelinase, and JNK activation. Apoptosis12:2013–2024, 2007.
156.
Gao D, Xiao Z, Lu AE. [Proliferation inhibition and apoptosis induction of K562 cells by D-limonene]. Zhongguo Shi Yan Xue Ye Xue Za Zhi14:1120–1122, 2006.
157.
Xiao D, Pinto JT, Soh JW, Deguchi A, Gundersen GG, Palazzo AF, Yoon JT, Shirin H, Weinstein IB. Induction of apoptosis by the garlic-derived compound S-allylmercaptocysteine (SAMC) is associated with microtubule depolymerization and c-Jun NH(2)-terminal kinase 1 activation. Cancer Res63:6825–6837, 2003.
158.
Munday R, Munday CM. Selective induction of phase II enzymes in the urinary bladder of rats by allyl isothiocyanate, a compound derived from Brassica vegetables. Nutr Cancer44:52–59, 2002.
159.
Laky B, Knasmuller S, Gminski R, Mersch-Sundermann V, Scharf G, Verkerk R, Freywald C, Uhl M, Kassie F. Protective effects of Brussels sprouts towards B[a]P-induced DNA damage: a model study with the single-cell gel electrophoresis (SCGE)/Hep G2 assay. Food Chem Toxicol40:1077–1083, 2002.
160.
Srivastava SK, Xiao D, Lew KL, Hershberger P, Kokkinakis DM, Johnson CS, Trump DL, Singh SV. Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo. Carcinogenesis24:1665–1670, 2003.
161.
Chen D, Landis-Piwowar KR, Chen MS, Dou QP. Inhibition of proteasome activity by the dietary flavonoid apigenin is associated with growth inhibition in cultured breast cancer cells and xenografts. Breast Cancer Res9:R80, 2007.
162.
Torkin R, Lavoie JF, Kaplan DR, Yeger H. Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuro-blastoma. Mol Cancer Ther4:1–11, 2005.
163.
Chaudhary A, Willett KL. Inhibition of human cytochrome CYP 1 enzymes by flavonoids of St. John’s wort. Toxicology217:194–205, 2006.
164.
Long X, Fan M, Bigsby RM, Nephew KP. Apigenin inhibits antiestrogen-resistant breast cancer cell growth through estrogen receptor-alpha-dependent and estrogen receptor-alpha-independent mechanisms. Mol Cancer Ther7:2096–2108, 2008.
165.
Way TD, Lin JK. Role of HER2/HER3 co-receptor in breast carcinogenesis. Future Oncol1:841–849, 2005.
166.
Chen D, Daniel KG, Chen MS, Kuhn DJ, Landis-Piwowar KR, Dou QP. Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells. Biochem Pharmacol69:1421–1432, 2005.
167.
Shukla S, Gupta S. Molecular targets for apigenin-induced cell cycle arrest and apoptosis in prostate cancer cell xenograft. Mol Cancer Ther5:843–852, 2006.
168.
Morrissey C, O’Neill A, Spengler B, Christoffel V, Fitzpatrick JM, Watson RW. Apigenin drives the production of reactive oxygen species and initiates a mitochondrial mediated cell death pathway in prostate epithelial cells. Prostate63:131–142, 2005.
169.
Watanabe N, Hirayama R, Kubota N. The chemopreventive flavonoid apigenin confers radiosensitizing effect in human tumor cells grown as monolayers and spheroids. J Radiat Res (Tokyo)48:45–50, 2007.
170.
Zhang Q, Zhao XH, Wang ZJ. Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem Toxicol46: 2042–2053, 2008.
171.
Das A, Banik NL, Ray SK. Mechanism of apoptosis with the involvement of calpain and caspase cascades in human malignant neuroblastoma SH-SY5Y cells exposed to flavonoids. Int J Cancer119:2575–2585, 2006.
172.
Brusselmans K, Vrolix R, Verhoeven G, Swinnen JV. Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity. J Biol Chem280:5636–5645, 2005.
173.
Miyoshi N, Naniwa K, Yamada T, Osawa T, Nakamura Y. Dietary flavonoid apigenin is a potential inducer of intracellular oxidative stress: the role in the interruptive apoptotic signal. Arch Biochem Biophys466:274–282, 2007.
174.
Mirzoeva S, Kim ND, Chiu K, Franzen CA, Bergan RC, Pelling JC. Inhibition of HIF-1 alpha and VEGF expression by the chemo-preventive bioflavonoid apigenin is accompanied by Akt inhibition in human prostate carcinoma PC3-M cells. Mol Carcinog47:686–700, 2008.
175.
Choi HJ, Eun JS, Kim BG, Kim SY, Jeon H, Soh Y. Vitexin, an HIF-1alpha inhibitor, has anti-metastatic potential in PC12 cells. Mol Cells22:291–299, 2006.
176.
Shukla S, Gupta S. Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation. Free Radic Biol Med44:1833–1845, 2008.
177.
Lee SH, Ryu JK, Lee KY, Woo SM, Park JK, Yoo JW, Kim YT, Yoon YB. Enhanced anti-tumor effect of combination therapy with gemcitabine and apigenin in pancreatic cancer. Cancer Lett259:39–49, 2008.
178.
Siddique YH, Beg T, Afzal M. Antigenotoxic effect of apigenin against anti-cancerous drugs. Toxicol In Vitro22:625–631, 2008.
179.
van Meeuwen JA, Nijmeijer S, Mutarapat T, Ruchirawat S, de Jong PC, Piersma AH, van den Berg M. Aromatase inhibition by synthetic lactones and flavonoids in human placental microsomes and breast fibroblasts—a comparative study. Toxicol Appl Pharmacol228:269–276, 2008.
180.
Horinaka M, Yoshida T, Shiraishi T, Nakata S, Wakada M, Sakai T. The dietary flavonoid apigenin sensitizes malignant tumor cells to tumor necrosis factor-related apoptosis-inducing ligand. Mol Cancer Ther5:945–951, 2006.
181.
Balasubramanian S, Eckert RL. Keratinocyte proliferation, differentiation, and apoptosis—differential mechanisms of regulation by curcumin, EGCG and apigenin. Toxicol Appl Pharmacol224:214–219, 2007.
182.
Shankar S, Chen Q, Sarva K, Siddiqui I, Srivastava RK. Curcumin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells: molecular mechanisms of apoptosis, migration and angiogenesis. J Mol Signal2:10, 2007.
183.
Shankar S, Srivastava RK. Involvement of Bcl-2 family members, phosphatidylinositol 3′-kinase/AKT and mitochondrial p53 in curcumin (diferulolylmethane)-induced apoptosis in prostate cancer. Int J Oncol30:905–918, 2007.
184.
Pandey BN, Mishra KP. Modification of thymocytes membrane radiooxidative damage and apoptosis by eugenol. J Environ Pathol Toxicol Oncol23:117–122, 2004.
185.
Atsumi T, Fujisawa S, Satoh K, Sakagami H, Iwakura I, Ueha T, Sugita Y, Yokoe I. Cytotoxicity and radical intensity of eugenol, isoeugenol or related dimers. Anticancer Res20:2519–2524, 2000.
186.
Yang Y, Yang L, You QD, Nie FF, Gu HY, Zhao L, Wang XT, Guo QL. Differential apoptotic induction of gambogic acid, a novel anticancer natural product, on hepatoma cells and normal hepatocytes. Cancer Lett256:259–266, 2007.
187.
Zhang HZ, Kasibhatla S, Wang Y, Herich J, Guastella J, Tseng B, Drewe J, Cai SX. Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay. Bioorg Med Chem12:309–317, 2004.
188.
Pandey MK, Sung B, Ahn KS, Kunnumakkara AB, Chaturvedi MM, Aggarwal BB. Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathway. Blood110:3517–3525, 2007.
189.
Liu W, Guo QL, You QD, Zhao L, Gu HY, Yuan ST. Anticancer effect and apoptosis induction of gambogic acid in human gastric cancer line BGC-823. World J Gastroenterol11:3655–3659, 2005.
190.
Wang T, Wei J, Qian X, Ding Y, Yu L, Liu B. Gambogic acid, a potent inhibitor of survivin, reverses docetaxel resistance in gastric cancer cells. Cancer Lett262:214–222, 2008.
191.
Zhao Q, Yang Y, Yu J, You QD, Zeng S, Gu HY, Lu N, Qi Q, Liu W, Wang XT, Guo QL. Posttranscriptional regulation of the telomerase hTERT by gambogic acid in human gastric carcinoma 823 cells. Cancer Lett262:223–231, 2008.
192.
Qiang L, Yang Y, You QD, Ma YJ, Yang L, Nie FF, Gu HY, Zhao L, Lu N, Qi Q, Liu W, Wang XT, Guo QL. Inhibition of glioblastoma growth and angiogenesis by gambogic acid: an in vitro and in vivo study. Biochem Pharmacol75:1083–1092, 2008.
193.
Palozza P, Maggiano N, Calviello G, Lanza P, Piccioni E, Ranelletti FO, Bartoli GM. Canthaxanthin induces apoptosis in human cancer cell lines. Carcinogenesis19:373–376, 1998.
194.
Moteki H, Hibasami H, Yamada Y, Katsuzaki H, Imai K, Komiya T. Specific induction of apoptosis by 1,8-cineole in two human leukemia cell lines, but not a in human stomach cancer cell line. Oncol Rep9: 757–760, 2002.
195.
Escribano J, Alonso GL, Coca-Prados M, Fernandez JA. Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro. Cancer Lett100:23–30, 1996.
196.
Miyahara Y, Hibasami H, Katsuzaki H, Imai K, Komiya T. Sesamolin from sesame seed inhibits proliferation by inducing apoptosis in human lymphoid leukemia Molt 4B cells. Int J Mol Med7:369–371, 2001.
197.
Aratanechemuge Y, Komiya T, Moteki H, Katsuzaki H, Imai K, Hibasami H. Selective induction of apoptosis by ar-turmerone isolated from turmeric (Curcuma longa L) in two human leukemia cell lines, but not in human stomach cancer cell line. Int J Mol Med9:481–484, 2002.
198.
Hanahan D, Weinberg RA. The hallmarks of cancer. Cell100:57–70, 2000.
199.
Bakhle YS. COX-2 and cancer: a new approach to an old problem. Br J Pharmacol134:1137–1150, 2001.
200.
Amati B, Alevizopoulos K, Vlach J. Myc and the cell cycle. Front Biosci3:d250–268, 1998.
201.
Smith TK, Lund EK, Parker ML, Clarke RG, Johnson IT. Allyl-isothiocyanate causes mitotic block, loss of cell adhesion and disrupted cytoskeletal structure in HT29 cells. Carcinogenesis25: 1409–1415, 2004.
202.
Awad AB, Williams H, Fink CS. Phytosterols reduce in vitro metastatic ability of MDA-MB-231 human breast cancer cells. Nutr Cancer40:157–164, 2001.
203.
Jin G, Zhang T, Wang T, Yang LP. [Inhibition of alpha-interferon and cinnamic acid on proliferation of human lung cancer cell]. Ai Zheng21:860–862, 2002.
204.
Yuan JP, Ling H, Zhang MX, Liu Y, Song Y, Su Q. [Diallyl disulfide-induced G2/M arrest of human gastric cancer MGC803 cells involves activation of p38 MAP kinase pathways]. Ai Zheng23:169–172, 2004.
205.
Shirin H, Pinto JT, Kawabata Y, Soh JW, Delohery T, Moss SF, Murty V, Rivlin RS, Holt PR, Weinstein IB. Antiproliferative effects of S-allylmercaptocysteine on colon cancer cells when tested alone or in combination with sulindac sulfide. Cancer Res61:725–731, 2001.
206.
Ujiki MB, Ding XZ, Salabat MR, Bentrem DJ, Golkar L, Milam B, Talamonti MS, Bell RH Jr, Iwamura T, Adrian TE. Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest. Mol Cancer5:76, 2006.
207.
Ghosh R, Nadiminty N, Fitzpatrick JE, Alworth WL, Slaga TJ, Kumar AP. Eugenol causes melanoma growth suppression through inhibition of E2F1 transcriptional activity. J Biol Chem280:5812–5819, 2005.
208.
Balasubramanian S, Zhu L, Eckert RL. Apigenin inhibition of involucrin gene expression is associated with a specific reduction in phosphorylation of protein kinase Cdelta Tyr311. J Biol Chem281: 36162–36172, 2006.
209.
Qin Y, Meng L, Hu C, Duan W, Zuo Z, Lin L, Zhang X, Ding J. Gambogic acid inhibits the catalytic activity of human topoisomerase IIalpha by binding to its ATPase domain. Mol Cancer Ther6:2429–2440, 2007.
210.
Yu J, Guo QL, You QD, Zhao L, Gu HY, Yang Y, Zhang HW, Tan Z, Wang X. Gambogic acid-induced G2/M phase cell-cycle arrest via disturbing CDK7-mediated phosphorylation of CDC2/p34 in human gastric carcinoma BGC-823 cells. Carcinogenesis28:632–638, 2007.
211.
Noujaim D, van Golen CM, van Golen KL, Grauman A, Feldman EL. N-Myc and Bcl-2 coexpression induces MMP-2 secretion and activation in human neuroblastoma cells. Oncogene21:4549–4557, 2002.
212.
Rosette C, Roth RB, Oeth P, Braun A, Kammerer S, Ekblom J, Denissenko MF. Role of ICAM1 in invasion of human breast cancer cells. Carcinogenesis26:943–950, 2005.
213.
Lee HS, Seo EY, Kang NE, Kim WK. [6]-Gingerol inhibits metastasis of MDA-MB-231 human breast cancer cells. J Nutr Biochem19:313–319, 2008.
214.
Tantivejkul K, Vucenik I, Shamsuddin AM. Inositol hexaphosphate (IP6) inhibits key events of cancer metastasis: II. Effects on integrins and focal adhesions. Anticancer Res23:3681–3689, 2003.
215.
Piantelli M, Rossi C, Iezzi M, La Sorda R, Iacobelli S, Alberti S, Natali PG. Flavonoids inhibit melanoma lung metastasis by impairing tumor cells endothelium interactions. J Cell Physiol207:23–29, 2006.
216.
Czyz J, Madeja Z, Irmer U, Korohoda W, Hulser DF. Flavonoid apigenin inhibits motility and invasiveness of carcinoma cells in vitro. Int J Cancer114:12–18, 2005.
217.
McMahon G. VEGF receptor signaling in tumor angiogenesis. Oncologist5Suppl 1:3–10, 2000.
218.
Thejass P, Kuttan G. Allyl isothiocyanate (AITC) and phenyl isothiocyanate (PITC) inhibit tumour-specific angiogenesis by down-regulating nitric oxide (NO) and tumour necrosis factor-alpha (TNF-alpha) production. Nitric Oxide16:247–257, 2007.
219.
Fang J, Zhou Q, Liu LZ, Xia C, Hu X, Shi X, Jiang BH. Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression. Carcinogenesis28:858–864, 2007.
220.
Yoysungnoen P, Wirachwong P, Bhattarakosol P, Niimi H, Patumraj S. Antiangiogenic activity of curcumin in hepatocellular carcinoma cells implanted nude mice. Clin Hemorheol Microcirc33:127–135, 2005.
221.
Yi T, Yi Z, Cho SG, Luo J, Pandey MK, Aggarwal BB, Liu M. Gambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling. Cancer Res68:1843–1850, 2008.
222.
Fang J, Xia C, Cao Z, Zheng JZ, Reed E, Jiang BH. Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways. FASEB J19:342–353, 2005.
223.
Tan WF, Lin LP, Li MH, Zhang YX, Tong YG, Xiao D, Ding J. Quercetin, a dietary-derived flavonoid, possesses antiangiogenic potential. Eur J Pharmacol459:255–262, 2003.
