Abstract
Summary
Five-hundred microcuries Cr51 tagged red blood cells and 125 microcuries I131 tagged serum albumin was injected into 8 sodium pentobarbital anesthetized dogs and blood samples collected simultaneously from the femoral artery and splenic vein. Time for red cell equilibrium was 59.3 minutes (22.5 to 87.5 minutes). Plasma equilibrium time was 16.5 minutes (3.5 to 32.5 minutes); red cell mean transit time was 10.09 minutes (6.8 to 39.82 minutes). Plasma mean transit time was 3.75 minutes (0.72 to 8.28 minutes). Average hematocrit of the spleen was 77.6 (65 to 88). Ratio of splenic hematocrit to large vessel hematocrit was 1.96 ± .12 S.D. over a range of arterial hematocrits from 31 to 49.5.
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