Abstract
Summary
The influence of urine volume upon excretion of corticoids has been determined in normal human subjects. There was a direct correlation with increases in urine volume resulting in an increase in steroid output whether measurement was made on a long time basis (day by day), or a short time basis (minute by minute). Subjects tested under waterloads and salt loads and with ADH also demonstrated the same positive correlation. As a corollary, clearances of steroids were measured and found to be about 1 ml/min. for free corticoids and about 4 ml/min. for bound steroids.
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