Abstract
Summary
Comparison of monoamine oxidase (MAO) inhibiting properties of iproniazid and its phenyl congener, 1-isonicotinyl-2-phenylisopropylhydrazine (isonicotinyl-PIH) showed it to be 1.5 to 2 times as effective in inhibiting MAO both in vitro and in vivo. The results indicate that the addition of a phenyl group to the isopropyl chain of iproniazid enhances MAO inhibitory properties. Comparisons with beta-phenyl-isopropylhydrazine also indicate that the isonicotinyl group hinders the MAO inhibiting property of the former compound.
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