Concentrative uptake of 6-Diazo-5-Oxo-L-Norleucine by Sarcoma 180,Liver and Muscle in vivo. ∗ †

Abstract

Summary

DON is concentrated intracellularly in S 180 and liver to levels 5-fold and 4-fold higher respectively than the extracellular concentration at a plasma level of 0.8–0.9 mM/kilo of plasma water. Intracellular concentrations in skeletal muscle were the same or less than the extracellular.