Abstract
Summary
Serum fraction VI from a bovine source showed on paper electrophoretic separation the presence of a glycoprotein band capable of binding I131 labeled thyroxine to the exclusion of other proteins present. On being given intravenously in the tail of rats, bovine fraction VI gave a marked depression in conversion ratio of inorganic to protein-bound iodine. This effect was shown to be due neither to a foreign protein reaction nor to a decreased body retention of iodine. The uptake of iodide ion by the thyroid gland did not appear to be the cause of this depressed conversion ratio.
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