Abstract
Summary
Twenty-seven white male Wistar rats weighing 450 g at beginning of the experiment were given a diet that induced a state of hyperlipaemia and produced vascular injury. This diet, arrived at as a result of several pilot experiments, proved to be very effective, and yielded the following incidence of coronary lesions: Lipomatous coronary changes 88%. Atheromatous coronary changes 81%. Atherosclerotic coronary changes 63%. Coronary occlusion 33%. Cardiac infarcts 14%.
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