Abstract
Summary
Atheromatous changes developed on the intimal surface of nylon and orlon thoracic-aortic vascular replacements in 2 of 6 dogs with induced chronic hypercholesterolemia. In both animals high serum cholesterol concentrations were maintained for over one year before the changes became evident. This is the first report of induced atheromatous change in a synthetic vascular prosthesis and may shed some light on the mechanism by which such changes occur.
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