Abstract
Summary
1. It has been demonstrated that retrobulbar injection of type A botulinus toxin in rabbits followed in 15 minutes by systemic administration of type A botulinus antitoxin produces a dilated fixed pupil in the eye on the injected side. 2. The dilated fixed pupil results from a block of the parasympathetic efferent nerves synapsing in the ciliary ganglion. This block is produced by the botulinus toxin. 3. Such a block persists in the intact animal at least 6 months without interference to nerve transmission of sympathetic or somatic pathways elsewhere in the animal.
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