Abstract
Summary
Conversion of glucose to lactate by ascites tumor cells derived from the Ehrlich carcinoma, Crocker sarcoma 180, and Freund sarcoma is stimulated by 4,6-dinitro-o-cresol under both aerobic and anaerobic conditions. Degree of stimulation increases as temperature is lowered from 37° to 15°, although the absolute rate of lactate production diminishes. Aerobic lactate production is stimulated to a greater degree than anaerobic and the former exceeds the latter under certain conditions. The implications and possible mechanisms of these phenomena are discussed.
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