Abstract
Summary
Intravenous injections of the surface active agent Triton WR1339 into rabbits caused a marked increase in serum neutral fat as well as in cholesterol and phospholipids. A large percentage of this increase was found in the lipid fraction which rose to the surface when serum was centrifuged at 20,000 g for 2 hours or more. Administration of Triton to rabbits rendered hypercholesterole-mic by cholesterol feeding decreased the percentage and absolute value of total cholesterol remaining in the subnatant fraction after highspeed centrifugation. After several injections, concentration of cholesterol in the subnatant dropped well below the pre-injection value in spite of increase in total serum cholesterol concentration. It is suggested that an increase in percentage of the cholesterol associated with chylomicrons together with a probable decrease in the fraction associated with lipomicrons might be factors in Triton-induced inhibition of development of atherosclerosis in cholesterol-fed rabbits.
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