Abstract
Summary
1. Maleuric acid produced mitotic inhibition in onion root-tip cells and an increase in proportion of mitotic cells in meta-phase, but little or no cytoplasmic or nuclear abnormality was observed. 2. A single intraperitoneal injection of maleuric acid into mice bearing the Ehrlich ascites tumor resulted in marked cytoplasmic blebbing of the tumor cells. Mitotic abnormalities produced by the treatment persisted for prolonged periods. 3. The affected tumor cells showed essentially normal patterns of free amino acids.
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