Abstract
Summary
1) Acquired tolerance to isolo-gous male skin may be produced in female mice of the A and C57 Bl (subline I) strains by injection at birth of living spleen cells taken from isologous adult male donors. The results show that by this procedure sex-determined incompatibility observed between male and female mice of these 2 strains may be overcome. 2) These observations are interpreted as providing evidence for the immunological basis of male skin graft rejection by isologous females.
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