Abstract
Summary
Human blood was incubated in vitro with the sodium salts of a number of di- and tricarboxylic acids and their effect on clotting time was noted. Cis-aconitate, trans-aconitate, isocitrate and tricarballylate markedly increased clotting time of whole blood. Prolongation of clotting in the presence of isocitrate and cis-aconitate was dependent upon their concentration in blood. The possible mode of action of these metabolically active compounds and the implications of the findings were discussed.
Get full access to this article
View all access options for this article.