Abstract
Summary
1. It is shown that a single intravenous injection of BCG in mice induces a state of hyperreactivity to bacterial endotoxin. The LD50 for E. coli lipopolysaccharide is decreased from 357 μg in controls to 6 or 7 μg in BCG vaccinated animals. This change appears around the 5th day after vaccination. 2. Trehalose dimycolate, a component derived from virulent tubercle bacilli induces a similar state of hyperreactivity to endotoxin upon single or repeated injections.
Get full access to this article
View all access options for this article.