Inhibitory Effect of a Serum Protein on Development of Opalescence in Lipoproteins Altered by Lecithinase C. ∗

Abstract

Summary

1. Hydrolysis of phospholipids of horse serum is not always accompanied by development of turbidity. 2. Although α1 ₁ lipoprotein fractions from horse sera become opalescent with or without development of a precipitate following hydrolysis of the phospholipids by lecithinase C, cholesterol and the diglyceride portion of phospholipids remain bound to protein. 3. L-FP (a lipid-free protein present in human and horse sera) suppresses development of opalescence in α1 ₁ lipoprotein fractions and whole human sera in which phospholipids are hydrolyzed by lecithinase C.