Abstract
Summary
C3H/He Crgl virgin female mice were ovariectomized at approximately monthly intervals between 2 and 8.5 months, and the mammary glands were examined at the time of mammary tumor development. Normal alveolar development of the mammary gland was greatest in animals ovariectomized at an early age and less in animals ovariectomized at later ages. In mice ovariectomized at 6.5 and 8.5 months, normal alveolar development was absent, the sole alveolar development being in the form of hyperplastic nodules. The secretory products of the transformed adrenal in the older mice thus appear to be adequate for development of hyperplastic nodules, but not for normal alveoli.
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