Effect of a High Protein and High Nucleic Acid Diet on Occurrence of 2- Acetylaminofluorene-induced Cancer in Rats. ∗

Abstract

Summary

1. The substitution of 5% high (6%) nucleic acid yeast for casein in a synthetic diet containing 45% casein and 0.06% 2-acetylaminofluorene significantly increased average survival of the rats but did not prevent development of the induced neoplasms. 2. Substitution of 1, 2, or 5% purified desoxyribonucleic acid or 5% Brewers yeast for casein in similar diets did not affect average survival period or frequency of occurrence of the induced neoplasms. 3. The high protein diet appeared to accelerate occurrence of the acetylaminofluorene-induced squamous cell carcinomas of the external auditory meatus.