Biliary Excretion of Co 60 Labeled Vitamin B 12 in Dogs. ∗

Abstract

Conclusions

1. Following intravenous administration of 2.09 to 3.48 μc Co⁶⁰ Vit. B₁₂ to dogs between 2.6 and 6.6% of radioactivity was recovered in the bile. 2. In 3 of 5 dogs the 2-phased excretion pattern showed fast and slow components of 6.0 to 7.5 hours and 90 to 295 hours, respectively. 3. Fecal excretion of radioactivity in dogs with biliary fistulae was considerably less than in intact normal animals.