Abstract
Summary
1. The reaction product of codeine and appropriate synthetic ion exchange resins has been demonstrated to possess analgetic properties of codeine. The resin-complex has a longer duration of action than does soluble forms of the drug. 2. Codeine analgesia has been potentiated by methylatropine and 2-methyl-3-orthotolyl-4-quinazolone. Both the resin complex and soluble salt forms of codeine are potentiated by these agents. 3. Resin reaction products of methylatropine and 2-methyl-3-orthotolyl-4-quinazolone have been prepared. Both of the drug resin combinations exhibit prolongation of action, including the property of codeine potentiation, the latter drug beng more potent in this respect. 4. Combinations of codeine-resin complex and of methylatropine or 2-methyl-3-orthotolyl-4-quinazolone in resin complex form are potent, long acting analgesics in the rat. 5. Analgesiometric data obtained in the rat by the D'Amour-Smith method have been treated so as to express both duration and intensity of action. More weight is given to duration of adequate analgesia than to intensity of analgesia.
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