Abstract
Conclusions
1. The localized Shwartzman reaction was produced in 62% of 265 New Zealand albino rabbits, using 3 different toxins (a meningococcal agar washings toxin, a partially purified “polysaccharide toxin” prepared from a culture of Serratia marcescens, and a crude Serratia marcescens agar washing toxin). Using these same toxins, localized Shwartzman reactions could not be induced in 15 Macacca mulatta monkeys, 20 mongrel dogs, 16 guinea pigs, 15 Wistar albino rats, 16 small swine (Hormel “Minipigs”), and 4 Toggenburg goats. 2. One post-partum lactating female goat developed a typical “generalized Shwartzman reaction” (i.e. renal cortical hemorrhagic necrosis).
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