Abstract
Summary
(1) The observations reported by Stewart and Eddy have been confirmed and extended by using inbred strains of mice, rats, and hamsters treated with tissue culture fluids prepared by Stewart and Eddy and at this laboratory. (2) Injection of such tissue culture fluids into newborn and young animals produced multiple types of tumors in mice of DBA/1, Swiss/ICR-Ha, C57 Black/Ha, AKR x Swiss F1, and AKR/Sn strains as well as in hamsters and rats. (3) Although most control tissue culture fluids possessed no tumor inducing ability, in one instance a control tissue culture fluid (line 1) did produce parotid tumors in 2 DBA/mice, 1 Swiss/ICR-Ha mouse, and multiple tumors in 1 hamster. (4) Transplantation of some of these induced tumors occurring in inbred mouse strains has been successful into the strain of origin if newborn and preconditioned irradiated hosts are used.
Get full access to this article
View all access options for this article.