Abstract
Summary
1) Glucagon is as active a glycogenolytic agent when administered subcutaneously as it is by intraperitoneal or intravenous route. However increases in blood glucose may not be observed following subcutaneous administration of glucagon, even though liver glycogen is almost completely mobilized. In adrenodemedullated animals, this is the rule. 2) Total liver glycogen store of the rat is relatively small, compared to the capacity of glucose disposal mechanisms. Changes in rates of the major glucose disposal reactions can completely mask the anticipated effect of hepatic glycogenolysis on blood glucose concentration. Such changes may be induced by fluctuations of endogenous insulin secretion.
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