Inhibition of Carbonic Anhydrase

Abstract

Summary

1. Venous and tissue gas tensions in the rat have been estimated by use of artificially constructed subcutaneous gas pocket. Inhibition of carbonic anhydrase by acetazolamide results in a rise in venous and tissue CO₂ tension independent of change of oxygen tension. This effect is associated with hyperventilation and an increase in arterial CO₂ content. 2. These findings are interpreted as direct evidence of CO₂ retention resulting from interference in CO₂ transport by carbonic anhydrase inhibition.