Abstract
Summary
Tissue distribution of C14-labeled K. pneumoniae polysaccharide-complex has been studied in guinea pig and rat after intravenous, intraperitoneal and subcutaneous injection, and in the mouse and rabbit after intravenous injection. The polysaccharide entered the blood stream from the peritoneal cavity more rapidly in the rat than in the guinea pig, while absorption from subcutaneous tissues was more rapid in the guinea pig. After intravenous injection, there were marked differences in tissue concentration of labeled polysaccharide in the 4 animal species. By simple extraction procedures, approximately 30% of the label in liver and mesenteric lymph nodes of the rat has been recovered in a polysaccharide retaining the haptenic property of the original polysaccharide.
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