Effect of Different Intrinsic Factor Preparations on Co 60 Vit. B 12 Uptake in Rat Liver Slices

Abstract

Summary

(1) We have confirmed the work of Miller and Hunter and have shown that addition of hog intrinsic factor to rat liver slice will increase uptake of Cobalt⁶⁰ labeled Vit. B₁₂. (2) Gastric juices with intrinsic factor activity from other animal sources have different effects on this uptake and this is not correlated with intrinsic factor activity in the human or their ability to make Vit. B₁₂ non-dialyzable.