Effect of Route of Injection on Distribution and Excretion of Cortisol-4-C 14 in the Rat

Abstract

Summary

Rate of excretion of radioactivity by rats was more rapid after intracardiac injection of cortisol-4-C¹⁴ than after intravenous injection. In addition, after the latter route significantly larger quantities of radioactive material entered the skin immediately following injection. The most likely explanation for this difference is considered to be hemodynamic changes caused by heart puncture. The tail vein is the most suitable site of intravascular injection for studies of the fate of adrenal steroids in normal animals under basal conditions.