Abstract
Summary
1. A technic is described which makes it possible to administer drugs into the carotid or vertebral circulations of intact, freely moving cats repeatedly over a period of weeks or months. Observations and photographs have been made of the resulting neurological or psychological effects, accompanied in some instances by simultaneous electrical recording from the cortex and deeper structures. 2. The effect of intracarotid sodium pentobarbital is described as an example. This has produced ipsiversive circling, relaxation of the ipsilateral nictitating membrane, and contralateral paralysis, spasticity, and homonymous hemianopsia, the effects varying with dose. Unilateral EEG changes, characteristic of barbiturates, accompany the neurological symptoms and signs. The latency of onset is very short and all the effects are fully reversible in 5-10 minutes. The advantages of the technic are discussed.
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