Abstract
Summary
Rats were treated with cortisone, x-radiation and both agents in combination, and the effects noted on RNA and glycogen content of liver. The following observations were made on concentrations of RNA and glycogen relative to that of DNA: (1) Under various conditions of treatment. RNA content increased promptly to different degrees and returned to normal values at different times. Comparison of RNA content/liver in the present study, with those of DNA/nucleus in previous study, indicates that, in animals which received cortisone alone, the maximum increase in RNA was obtained 24 hours prior to a fall in concentration of DNA. However, accumulation of RNA in rats which received x-radiation or both cortisone and x-radiation was 48 hours earlier than when the fall of DNA became significant. (2) N-radiation or cortisone administration caused glycogen accumulation in liver, the former transiently, the latter in more dramatic and prolonged manner. X-radiation, prior to administration of cortisone, modified the response and decreased glycogen accumulation. Changes in glycogen content in contradistinction to RNA could not be correlated with those of DNA.
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