Abstract
Summary and conclusion
Chemical analysis of rat skin was independent of the area from which the sample was taken. Increases in hexosamine and decreases in hydroxyproline concentration found in skin necrotized with croton oil was paralleled to a lesser degree in uninjured skin. This systemic response was also found as an increase in circulating concentration of hydroxyproline in blood. Despite the statistical significance of these changes, the markedly increasing ratio of hexosamine to hydroxyproline in necrotic tissue with time was not paralleled significantly by the control.
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