Abstract
Summary
Organic phosphate insecticides. OMPA, EPN, malathion, chlorothion and phostex, which are rapidly metabolized in liver, markedly increased hexobarbital sleeping time in mice, while BFP and TEPP did not. Malathion and chlorothion did not alter toxicity of hexobarbital. TEPP hastened onset of action of barbital while chlorothion did not. Certain anticholinesterases which are rapidly metabolized by liver may compete for enzymes which are responsible for destruction of hexobarbital.
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