Abstract
Summary
When rats are swimming at 19 or 28°C, swimming time is markedly reduced by chlorpromazine (10 mg/kg) treatment. This difference is not due to differences in body temperature but is probably caused by sedation and muscular paralysis caused by this drug. At 9°C the detrimental effect of bath temperature on swimming time is so marked that chlorpromazine fails to display any action whereas at 32°C the stress is so small as to allow the animal to perform as well even when treated with chlorpromazine.
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