Effect of Phenethylbiguanide on Adrenal Function and Responsiveness as Measured by ACTH Test. ∗

Abstract

Summary

Adrenal function was studied in 6 diabetic patients with hyperglycemia controlled by DBI (N B' phenethylformadinylimourea) or by DBI and insulin. DBI administration did not significantly affect baseline plasma hydrocortisone levels or response to ACTH. These results appear to eliminate adrenal steroid suppression as a possible mode of action of this biguanide.