Abstract
Summary
1. Dietary restriction of copper in adult rats was followed by prompt decrease in serum copper and a somewhat slower and less extensive depletion of liver copper. 2. Feeding of diets high in copper was followed by increase in concentration of copper in both serum and liver. The increase occurred more rapidly in serum than in liver during the first 20 days. Thereafter, rate of increase was greater in liver than in serum. 3. It is concluded that concentration of copper in serum and liver is markedly influenced by dietary intake of copper and that there is a close correlation between serum and liver copper concentrations.
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