Abstract
Summary
(1) One or 2 doses of 7 mg/kg of TC or 2.5 mg/kg of MC destroyed the litters of rats when given after 10th day of gestation period. (2) Placentas survived the fetuses. (3) Maternal response to dosage consisted in depression of myeloid tissues of bone marrow, peripheral WBC and prothrombin time. (4) Four consecutive litter destructions in utero with TC were well tolerated by a group of rats, did not impair their subsequent fertility or reproduction, nor cause abnormalities in subsequent offspring. (5) The same doses of TC or MC given prior to fertilization, or implantation were less effective in litter destruction.
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