Control Mechanisms for Trauma Induced DLSH Reaction (Decrease in Mouse Liver Non-Protein Sulfhydryl). ∗

Abstract

Summary

A DLSH reaction (statistically significant decrease in liver NPSH) was secured in mice by administration of very large amounts of insulin, epinephrine or nor-epinephrine, or tourniquet traumatization. Trauma was as effective in inducing a DLSH reaction in alloxan diabetic or adrenal demedullated mice as in normal mice; hence the trauma induced DLSH reaction was not attributable to endogenous insulin or adrenal medullary hormones. The trauma induced DLSH reaction was practically abolished by either adrenalectomy or administration of the ganglion blocking drug chlorisondamine dimethochloride. This indicates that both adrenal cortical and sympathetic nervous system activities are required for the reaction.